I was asked by a fellow nurse recently what I think is the best way to get a principal investigator (PI) more engaged. She expressed frustration with her PI and did not want to be bothered by study-related issues. There is a method to getting PIs more involved, but you first must ask yourself why they are doing research in the first place. From the business side, sites are trying to analyze the cost of doing research daily, and fortunately (or maybe unfortunately), that is becoming more of a drain on sites. PIs and research staff have less time than they previously did to do the mundane tasks that bring in little to no revenue. As studies become more complex with less staff, how do we keep PIs feeling that research is worth it?